Histopathology of hepatocellular carcinoma.

Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma and Hepatocellular Carcinoma Histopathology Reporting Guide

HISTOLOGICAL TUMOUR TYPE (Note 7) Hepatocellular carcinoma Hepatocellular carcinoma, fibrolamellar variant Cholangiocarcinoma Combined hepatocellular – cholangiocarcinoma Intraductal papillary neoplasm with an associated invasive carcinoma Mucinous cystic neoplasm with an associated invasive carcinoma Undifferentiated carcinoma Carcinoma, type cannot be determined mm Intrahepatic Cholangiocar...

Status of serum alpha feto-protein (AFP) and midkine (MDK) levels in patients with hepatocellular carcinoma

Introduction: Hepatocellular carcinoma (HCC) is sixth common cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of midkine (MDK) and α-fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC). Materials and methods: We studied MDK and AFP in patients with HCC or in healthy controls. MDK and AFP was measured by enzyme linked immuno...

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

Hepatocellular Carcinoma in Sheep

Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...

Evaluation of Silibinin effects on the Viability of HepG2 (Human hepatocellular liver carcinoma) and HUVEC (Human Umbilical Vein Endothelial) cell lines

Human hepatocellular carcinoma is one of the most common recurrent malignancies, for as much as, there is no effective therapy. Silibinin, a widely used drug and supplement for various liver disorders, demonstrated anticancer effects against human hepatocellular carcinoma, human prostate adenocarcinoma cells, human breast carcinoma cells, human ectocervical carcinoma cells, and human colon canc...